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Carbon nanotubes create artificial cell membrane channels th

2018-12-20    浏览:1324 次
These carbon nanotubes "membrane porins" have important implications for future health care and bioengineering. Carbon nanotubes will eventually be used to deliver drugs to the body, which can serve as the basis for new biosensors and DNA sequencing applications, and can be used to synthesize cell components.



Researchers have long been interested in the development of synthetic analogues of biomembrane channels, which can replicate highly efficient and highly selective transporters of particles and molecules, often found in natural systems. However, these efforts will always face some problems in synthetic science, and scientists seem never to be able to fully simulate the performance of biological proteins.



Generally, the tablets taken are slowly absorbed by the body and then transported to all parts of the body, but carbon nanotubes are different in that they can identify a precise area to be treated without harming other organs around them. "Many highly effective drugs for one organ disease can be toxic to other organs," says Aleksandr Noy, a biophysicist at Lawrence Livermore National Laboratory, who led the study. "That's why it's better to deliver drugs to specific areas of the body and release them there only." The study was published in the October 30 issue of Nature.



Lawrence Livermore National Laboratory's team and colleagues at Lawrence Berkeley National Laboratory's Molecular Materials Department, the University of California Merced and Berkeley, Spain's Basque National University have used carbon nanotubes to create a more efficient and biocompatible membrane pore channel. Carbon nanotubes are a suction-like molecule that contains a rolled-up graphite. Alkene film.



This study shows that although the structure of carbon nanotubes is relatively simple, poroproteins in carbon nanotubes have many characteristics of natural ion channels: they can spontaneously insert into cell membranes, switch between metastable conductance states, and exhibit typical polymer-induced barrier properties. The team also found that local channels and charged cell membranes could also control the ionic conductivity and ionic selectivity of porins in carbon nanotube membranes, similar to those in biological channels.

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